NAD+ Booster

Nicotinamide adenine dinucleotide (NAD+) is a crucial coenzyme that powers your cells, converting nutrients into energy while activating key enzymes like sirtuins for DNA repair, gene expression regulation, immune cell function and cellular stress responses (Covarrubias et al.) After decades of research, scientists now recognize it as fundamental to maintaining healthy cellular function throughout your body.

As we age, our NAD+ levels drop significantly by 10%–80%, which is linked to aging-related issues like diabetes, Alzheimer’s, and cancer (Freeberg et al., 2023). Maintaining or restoring NAD+ levels could support healthier aging and better overall health.Because NAD+ precursors are found only in trace amounts in nature, the body cannot rely on direct dietary sources to replenish it. Instead, oral supplement is clinically proven to efficiently raise NAD+ levels, helping to support cellular function.

Clinical trials conducted by Freeberg et al. (2023) have examined the safety and effectiveness of nicotinamide riboside (NR) supplementation in enhancing NAD+ levels in humans. The findings indicate that oral NR supplementation is safe, well-tolerated, and successfully increases NAD concentrations along with related metabolites in various tissues.

Although NAD+ is present in every cell of the body, the mitochondrial NAD+ pool plays a particularly crucial role, as it is essential for cell survival. However, mitochondrial NAD+ is not synthesized directly within the mitochondria. Instead, its production relies on precursors such as NMN and NR which are primarily found in the cytosol and nucleus. Other NAD+ precursors are too large to enter cells directly and must first be metabolically converted into NR to cross the cell membrane. This additional conversion step may affect their efficiency and overall effectiveness in boosting mitochondrial NAD+ levels.

At NatureNewborn, we use Nicotinamide Riboside Hydrogen Malate (NRHM)—a combination of NR and malate, a naturally occurring compound involved in cellular metabolism. This form is designed to be more stable, better tolerated, and potentially more bioavailable than standard NR.

Plus, NR is recognized by the U.S. FDA as a safe dietary supplement ingredient. NR has been shown to be safe in human clinical studies.

The most commonly reported side effects of NAD+ precursors include diarrhea, nausea, rashes, hot flashes, and leg cramps. These effects are generally rare and mild for most users. However, it’s a good idea to start with a lower dose to see how your body responds.

NatureNewborn NAD+ Booster can generally be combined with other dietary supplements, such as vitamin C, Vitamin D, quercetin, AMPK activators, or curcumin, as these compounds often complement NAD+ support pathways. However, we strongly recommend consulting a healthcare professional or nutritionist to ensure compatibility based on your individual health needs, medications, or preexisting conditions.

Our consumer studies show noticeable benefits—such as better sleep, increased energy, and reduced inflammation—within just two week. They are most effective when taken as part of your daily supplement routine. For best results, use consistently for at least 12 weeks. Individual results may vary.