Posted by NatureNewborn Research
on December 25, 2025
7 Million Americans are Living with Alzheimer's Disease
According to American Hospital Association, for the first time in history, more than 7 million Americans are living with Alzheimer’s Disease (AD). Nearly two-thirds of those with the disease are women. For individuals reaching age 65, the odds of developing AD are alarmingly high—approximately 1 in 9. This number is projected to rise significantly in the coming decades, making it one of the most urgent public health challenges of our time.
Symptoms of Alzheimer's Disease
Alzheimer's is a progressive disease, meaning symptoms develop gradually and become more severe over time. Common symptoms include:
- Memory loss that disrupts daily life (e.g., forgetting recently learned information or important dates).
- Challenges in planning or solving problems (e.g., trouble following a familiar recipe or keeping track of monthly bills).
- Confusion with time or place (e.g., losing track of dates, seasons, or the passage of time).
- Trouble understanding visual images and spatial relationships.
- New problems with words in speaking or writing.
- Withdrawal from work or social activities.
- Changes in mood and personality.
The Cause of Alzheimer's Disease
While the accumulation of plaques (amyloid-beta) and tangles (tau) has long been the primary focus of AD's research, newer science suggests these may be downstream effects of a deeper cellular failure. A compelling new theory points to a collapse in RNA splicing—the process by which cells "edit" genetic instructions to create functional proteins.
This collapse appears to be driven by the depletion of Nicotinamide Adenine Dinucleotide (NAD+). NAD+ is a critical coenzyme for cellular energy and repair. As we age, NAD+ levels drop naturally, but in Alzheimer's brains, this depletion is severe. Without sufficient NAD+, the machinery responsible for RNA splicing (specifically a protein called EVA1C) begins to make errors, leading to the buildup of toxic proteins and neuronal death.
How NAD+ Helps with Alzheimer's Disease
NAD+ does not just boost energy; it acts as a "correction mechanism" for genetic errors. Research has shown that replenishing NAD+ levels can restore the fidelity of RNA splicing.
Specifically, NAD+ activates a pathway involving the protein EVA1C. When NAD+ levels are restored, EVA1C is able to function correctly, fixing splicing errors in hundreds of genes that are critical for brain health. This process effectively reverses neurodegenerative damage caused by toxic tau proteins and improves memory function.
Moreover, practical research using mouse models has shown that supplementing with Nicotinamide Riboside (NR)—a safe precursor that the body turns into NAD+—has profound effects. NR supplementation normalized key features of the disease. It significantly reduced neuroinflammation, decreased DNA damage, and reduced toxic tau tangles. Crucially, the mice treated with NR showed improved cognitive function and better learning abilities compared to untreated mice.
How AKG Helps with Alzheimer's Disease
Alpha-Ketoglutarate (AKG) helps through a different but complementary pathway focused on cellular survival and "cleanup." AKG is a key molecule in the Krebs cycle (energy production) and regulates the mTOR pathway.
By modulating mTOR, AKG promotes autophagy, a process where cells "eat" and recycle their own damaged parts.
In Alzheimer's models, AKG has been shown to rescue synaptic deficits—meaning it helps reconnect the communication lines between neurons—and improve long-term potentiation (LTP), which is the cellular basis for learning and memory.
1+1 >2
The science is clear: supporting your cellular health with both NAD+ and AKG is a proactive step toward maintaining cognitive function as you age — think of one acting like a tiny immune system 'cleaner' to remove the roadblock in your brain, and the other aims to keep the brain cells alive.
NatureNewborn’s NAD+ Booster is uniquely formulated to leverage this dual-action science. Unlike other NAD+ supplements, our blend specifically combines NAD+ and AKG to target mitochondrial health, supporting both the cleanup process and the repair mechanism in your brain and body.
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Refernce:
- American Hospital Association
- Hou Y., Lautrup S., Cordonnier S., Wang Y., Croteau D. L., Zavala E., et al. (2018). NAD(+) supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. Proc. Natl. Acad. Sci. U.S.A. 115 E1876–E1885.
- Navakkode S, Kennedy BK. Alpha-Ketoglutarate Ameliorates Synaptic Plasticity Deficits in APP/PS1 Mice Model of Alzheimer's Disease. Aging Cell. 2025 Nov;24(11):e70235. doi: 10.1111/acel.70235. Epub 2025 Sep 17. PMID: 40959937; PMCID: PMC12610948.
- Ai R, Mao L, Jin X, Campos-Marques C, Zhang SQ, Pan J, Lagartos-Donate MJ, Cao SQ, Barros-Santos B, Nóbrega-Martins R, Katsaitis F, Yang G, Xie C, Kang X, Wang P, Novello M, Hu Y, Bergersen LH, Storm-Mathisen J, Kuroyanagi H, Escobar-Doncel B, González NV, Chaudhry FA, Wang Z, Zhang Q, Lu G, Sotiropoulos I, Niu Z, Chen G, Nair RR, Silva JM, Luo OJ, Fang EF. NAD+ reverses Alzheimer's neurological deficits via regulating differential alternative RNA splicing of EVA1C. Sci Adv. 2025 Nov 7;11(45):eady9811. doi: 10.1126/sciadv.ady9811. Epub 2025 Nov 7. PMID: 41202143; PMCID: PMC12594206.
